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Clinical Research

EB Journal Club

PALISI network

Surveys

NIH resources

Clinical Trials

Other grants
... in this section ...

    The National Institute of Child Health and Human Development (NICHD)

    • Collaborative Pediatric Critical Care Research Network (CPCCRN)
      • Willson DF, Dean JM, Newth C, et al. Collaborative Pediatric Critical Care Research Network (CPCCRN)* Pediatr Crit Care Med. 2006 Jul;7(4):301-307. [abstract]

    • The Pediatric Critical Care Scientist Development Program (PCCSDP) has been successfully reissued by the NICHD. Read the RFA here... This program has been funded to foster the development of highly promising young faculty in pediatric critical care into physician scientists [updated]

      The PCCSDP is accepting application for Scholar positions to begin funding January 1, 2009. This program has funded 15 Scholars to date. Information on this program is available at www.pccsdp.org and details about the PCCSDP application procedure are available in the brochure here... (pdf; 120K)

      Carol Nicholson has developed and made available a Powerpoint file (428K) describing this program.

    • Multidisciplinary Translational Research in Critical Care: The National Institutes of Health (NIH) announce the availability of funds to promote multidisciplinary translational research that will improve the treatment, diagnosis, and outcome of patients with critical illness and increase the understanding of fundamental processes causing critical illness in humans of all ages. Read the full announcement: http://grants.nih.gov/grants/guide/pa-files/PA-07-233.html

    • NIH Program Announcement for EMSC research: "This multi-agency program announcement is designed to improve the quality and quantity of research related to emergency medical services for children (EMSC), with the goal of reducing morbidity and mortality in children through improved care delivery." Read the full text here...

    • PA-04-059: Technologies for Monitoring and Performing Resuscitation (SBIR [R43/R44])
      This funding opportunity will fostering development of better systems and methods for out-of-hospital and basic resuscitation research that:
      • enables monitoring of genetic, molecular, biochemical, physical or metabolic derangements associated with circulatory, hypoxemic, or traumatic arrest; and
      • elucidates the unique pathophysiology of irreversible injury following multiple organ or whole-body ischemia and reperfusion.

    • "Seeking Support From the NIH for Pediatric Critical Care Research" is an invaluable Powerpoint presentation by Carol Nicholson, MD, MS from the NIH/NICHD/NCMRR to anyone interested in seeking NIH funding. She has presented this at recent meetings and has now graciously made it publicly available. (Powerpoint file, 3.2 MB)

    • CDC funding opportunities of interest to Pediatric Critical Care:
      • Research Grants to Describe Traumatic Brain Injury Consequences
        • The funding announcement for Research Grants to Describe Traumatic Brain Injury Consequences (CE06-003) can be accessed at www.cdc.gov/od/pgo/funding/CE06-003.htm .
        • Approximately $650,000 is expected to be available.
        • One award will be funded.
        • Funding level will not exceed $650,000 (including both direct and indirect costs) per year.
        • Project period is up to five years.
        • The award mechanism is a R49 grant.
      • Research Grants for the Care of the Acutely Injured
        • The funding announcement for Research Grants for the Care of the Acutely Injured (CE06-005) can be accessed at www.cdc.gov/od/pgo/funding/CE06-005.htm .
        • Approximately $1,800,000 is expected to be available.
        • Three to five awards will be funded.
        • Funding level will not exceed $450,000 (including both direct and indirect costs) per year.
        • Project period is up to three years.
        • The award mechanism is a R49 grant.

    • Grants.gov is "a single, comprehensive Web site that will contain information about finding and applying for all federal grant programs."

    • Pediatric critical care research training fellowships:

      Be sure to scan the list of fellowships available for those with NIH Training Grant funding for pediatric scientist training...

    Important announcements

    The Robert Wood Johnson Clinical Scholars Program

    The Robert Wood Johnson Clinical Scholars Program is a two-year fellowship for physicians interested in clinical research and healthcare leadership. The fellowship provides rigorous training in clinical and health services research, health policy, and community-based health research. Under the guidance of mentors, Scholars will conduct two or more independent clinical research projects during the fellowship. The fellowship is offered at four sites: the University of California, the University of Michigan, the University of Pennsylvania, and Yale University. Physicians typically apply in their second year of residency, for a start date after the end of their third year of residency. Surgeons can apply in their first year of residency. Application deadline: February 29, 2008.

    For more detailed information and to obtain an application, please visit the Program website at http://rwjcsp.unc.edu/.

    Pediatric Xigris Trial Stopped

    Eli Lilly and Company has decided to stop enrollment in its Phase 3b clinical trial of Xigris in pediatric severe sepsis patients (Protocol F1K-MC-EVBP (resolve): Investigation of the Efficacy and Safety of Drotrecogin Alfa (activated) in Pediatric Severe Sepsis).

    This decision occurred on March 9th, 2005 following a recommendation by the Data Monitoring Committee to stop the study based on "futility due to an unfavorable benefit/risk profile" in pediatric patients with severe sepsis. Data collection continues and Lilly plans to disclose the study results as soon as possible.

    More details are now available in this letter of April 18, 2005 (pdf; 16K)

    PALISI; Pediatric Acute Lung Injury and Sepsis Investigators. [updated]

    • A focused network of PICUs "to perform multicenter clinical studies to discover evidence that can improve the clinical management of critically ill children suffering from acute lung injury and sepsis." More...

    Clinical Trial Registration: Required

    Want to publish your clinical trial in JAMA, The New England Journal, or other member journals of the International Committee of Medical Journal Editors? Starting July 2005 (for trials beginning enrollment after this date), your trial will need be registered in advance. Read DeAngelis CD, Drazen JM, Frizelle FA et al. Clinical Trial Registration: A Statement From the International Committee of Medical Journal Editors. JAMA 8 September 2004 (10.1001/jama.292.11.1363) [full-text].

    Go to www.clinicaltrials.gov to register a trial.

    An update: Laine C, et al. Clinical Trial Registration: Looking Back and Moving Ahead. New Engl J Med 2007; 10.1056/NEJMe078110 [full-text]

    The National Data Archive on Child Abuse and Neglect

    The National Data Archive on Child Abuse and Neglect is accepting applications for the 2005 Summer Research Institute (SRI). This message contains the Summer Research Institute 2005 Announcement and the Application questions.

    A full description is available as a Word file (52K) or pdf document (60K).

    The application is here: http://www.ndacan.cornell.edu/NDACAN/Workshops/SRI2005Application.html

    From the Centers for Disease Control and Prevention (CDC):

    Guillain Barre following Meningococcal Conjugate Vaccine

    The Food and Drug Administration (FDA) and Centers for Disease Control and Prevention (CDC) are alerting consumers and health care providers to five reports of Guillain Barre Syndrome (GBS) following administration of Meningococcal Conjugate Vaccine A, C, Y, and W135 (trade name Menactra), manufactured by Sanofi Pasteur. It is not known yet whether these cases were caused by the vaccine or are coincidental. FDA and CDC are sharing this information with the public now and actively investigating the situation because of its potentially serious nature.

    Because of the potentially serious nature of this matter, FDA and CDC are asking any persons with knowledge of any possible cases of GBS occurring after Menactra to report them to the Vaccine Adverse Event Reporting System (VAERS) to help the agencies further evaluate the matter. Individuals can report to VAERS on the web at www.vaers.hhs.gov or by phone at 1-800-822-7967. Read the complete alert: www.fda.gov/bbs/topics/NEWS/2005/NEW01238.html

    Acute Encephalopathy Cases in U.S. Children Associated with Influenza Virus Infection

    Since the mid-1990's, several hundreds of cases of acute encephalopathy have been reported in Japanese children with influenza. These cases have been characterized by fever and rapid onset of encephalopathy, resulting in a high frequency of neurological sequelae and mortality. Most of the children have had laboratory-confirmed evidence of influenza virus infection.

    To determine if a similar pattern of influenza-associated encephalopathy cases is occurring in the U.S., the Centers for Disease Control and Prevention (CDC) is requesting information from health care providers on any case meeting the following criteria:

    • < 18 years old;
    • Altered mental status, or personality change, lasting > 24 hours, occurring within 5 days of the onset of an acute febrile respiratory illness;
    • Laboratory or rapid diagnostic test evidence of acute influenza virus infection
    • Diagnosed in the U.S.

    Please report any suspected cases to either Dr. Tim Uyeki (404-639-0277; tmu0@cdc.gov) or Dr. Niranjan Bhat (404-639-2893; nib9@cdc.gov) at CDC.

    The CDC Study of Pulmonary Hemorrhage in Infants: a call for cases.

    Also see:

    Information about the Pediatric Critical Care Study Group

    • The premiere organization for multicenter clinical research in pediatric critical care is now part of The Virtual PICU

    PICUEs - Pediatric ICU Evaluations

    • PICUEs is now on the web and seeking research proposals. Contact Murray Pollack, MD, Director, at picues.org. (New version 3.0 software overview is here...)

    Network ARDS in Children

    • A prospective Internet-based data collection project studying ARDS in children.
    • Contact Dr. Lutz Bindl for more information on how to participate.

    Clinical Research Trials:

    Descriptions of studies available for additional collaborators

    • Seeking sites interested in participating in a NICHD funded study of the effects of sodium nitroprusside:

      Study: A PHASE II, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL GROUP STUDY TO DETERMINE THE PHARMACODYNAMICS OF SODIUM NITROPRUSSIDE DURING PROLONGED INFUSION IN PEDIATRIC SUBJECTS (Protocol Number: NICHD-2003-09-LT)

      Requirements: ≥12 bed PICU caring for infants and children with hypertension for which sodium nitroprusside may be administered for at least 12 hours. Sites should have the infrastructure to conduct relatively complex clinical trials.

      Interested investigators should contact Dr. Greg Hammer, Professor of Anesthesia and Pediatrics, Stanford University School of Medicine at ham@stanford.edu.

    • From Dr. Goldstein at Oregon Health & Sciences University: Traumatic Brain Injury Research Project: additional sites interested in participating in our physiologic waveform analysis and dynamic ICP modeling research project. Read more here...

    • Request for participation from Drs. Wong and Shanley at Cincinnati Children's:

      "... we have a large scale clinical study to conduct microarray analyses in children with septic shock. Specifically, we are proposing to develop a national-level genomic data base (RNA) of children with SIRS and septic shock. The data base will be mined to conduct high throughput microarray analyses to define the genome-level expression profiles in this patient population."

      More details and contact information is here (pdf file, 52K)...

    • A Pilot Study of Abnormal Acquired and Genetic Coagulation Factors in Children with Porencephaly and Stroke
    • Consider adding an outline of your trial to attract other interested investigators
    • National and International Databases of Clinical Research Trials

    Surveys of the pediatric critical care community?

    • Second Call: Survey on Traumatic Brain Injury

      A recent multidisciplinary effort resulted in the publication of the Guidelines for Acute Medical Management of Severe Traumatic Brain Injury in Infants, Children and Adolescents in July 2003. We are conducting a survey aimed at characterizing the treatment severe TBI in children and to compare current clinical practice to the July 2003 guidelines.

      This survey will provide important information on how the current level of evidence for management of severe TBI in children influences clinical practice and will assist the process for improvement in clinical practice strategies. We appreciate your time if you already completed the survey. Your responses will be confidential and blinded. If you have not done so, please help us out by going to the following web-site to fill out the survey:

      http://www.zoomerang.com/survey.zgi?p=WEB224HMD2C6XJ

      Thank you in advance for your participation in this important project.

      Nathan Dean, MD
      2nd year Fellow, Pediatric Critical Care
      St Louis Children's Hospital/ Washington University
      1 Children's Place
      St Louis, MO 63110
      Office- 314-454-2527
      Pager- 314-790-0135
      Fax- 314-361-0733
      Email- dean_n@kids.wustl.edu

      Jose A. Pineda, M.D.
      Assistant Professor of Pediatrics and Neurology
      Washington University School of Medicine
      Division of Critical Care Medicine
      Campus Box 8116
      One Children's Place, Suite 5S20
      St. Louis, Missouri 63110
      314-454-2545
      314-361-0733 fax
      Pineda_J@kids.wustl.edu

    • A survey for PICU advanced practice nurses and physician assistants:

      Advance Practice Nurses and Physician Assistants,

      This is YOUR CHANCE TO HAVE YOUR VOICE HEARD! We are gathering data on staffing options in pediatric intensive care units to present at the upcoming Society of Critical Care Medicine meeting in Phoenix in January. We need your thoughts and opinions in order to discuss and address national staffing needs in PICUs.

      Seize this chance to voice your opinions on this rapidly expanding arena and workforce! Please take 5 minutes to complete the enclosed survey. All responses will remain anonymous and the results will be complied and presented at the SCCM meeting in January 2005. Just click on the link below to complete the survey:

      http://web.admin.bcm.tmc.edu/ped/surveys/survey1.cfm

      Thank you for your input!

      Larry Jefferson MD. Texas Children's Hospital, Baylor College of Medicine

    • The CDC is interested in cases of severe pertussis in PICU's in the United States. Please download and complete this very brief survey (Word file, 24K) and return to Dr. Karen Broder at kbroder@cdc.gov.

    • Have a survey idea? Would you like it posted on PedsCCM? Email us for details.
    • Survey results:
      • Where are acuity lines drawn between PICU's and Transitional Care Units? Survey results from C. Adams, Kosair Children's Hospital, Louisville KY. (Powerpoint presentation 208K)

    Rare Diseases Clinical Research;

    Grant resources on the Internet


Last Updated: 2008-07-14 11:50:21
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