Study: A PHASE II, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL GROUP STUDY TO DETERMINE THE PHARMACODYNAMICS OF SODIUM NITROPRUSSIDE DURING PROLONGED INFUSION IN PEDIATRIC SUBJECTS (Protocol Number: NICHD-2003-09-LT)

Requirements: ≥12 bed PICU caring for infants and children with hypertension for which sodium nitroprusside may be administered for at least 12 hours. Sites should have the infrastructure to conduct relatively complex clinical trials.

Interested investigators should contact Dr. Greg Hammer, Professor of Anesthesia and Pediatrics, Stanford University School of Medicine at ham@stanford.edu.

"... we have a large scale clinical study to conduct microarray analyses in children with septic shock. Specifically, we are proposing to develop a national-level genomic data base (RNA) of children with SIRS and septic shock. The data base will be mined to conduct high throughput microarray analyses to define the genome-level expression profiles in this patient population."

More details and contact information is here (pdf file, 52K)...

We are looking for additional sites interested in participating in our physiologic waveform analysis and dynamic ICP modeling research project. Sites using Phillips (HP) Merlin bedside monitors are preferred. Our current research team includes faculty from pediatric and adult critical care, biomedical and electrical engineering, systems science, math, and physics. See the website of my colleague, James McNames, PhD at www.bsp.pdx.edu for an overview of our research team and some of our projects and publications. This is a great opportunity for a junior faculty or fellow interested in physiology and TBI. Anyone interested in learning more about this project, please contact me directly and I will arrange a time for a conference call to discuss the project in detail, send you the full research protocol and sample consent form, and send copies of pertinent recent research papers from our group.

Brahm Goldstein, MD, FCCM
Professor of Pediatrics
Director, Pediatric Clinical Research Office
Doernbecher Children's Hospital
Oregon Health & Sciences University
707 S.W. Gaines Road
Mail Code CDRCP
Portland, OR 97239
503-418-5177 tel
503-494-6052 fax
goldsteb@ohsu.edu